Brief Update: What’s New in the Field of Autism Genetics?
Unfortunately this week I’m bogged down with a lot of writing (grant, manuscript revision, etc.) and so my post is going to have to be rather short. But I wanted […]
Tag Archives: copy number variation
Alu Transposable Elements and the Human Genome
For those not familiar, transposable or mobile elements are segments of DNA that have, or at one time had, the potential for moving about the genome. This occurs either via […]
Common Genetic Variants & Autism Risk
A letter was published this month in Nature Genetics by Gaugier et al. which has received notable attention. While many of us may be familiar with rare variants of genes […]
“Why Are Some Genomes So F***ing Big???”
Good question. And it’s been asked before. Usually this question arises within the context of “What use is a larger genome?” when we consider vast genomes such as the onion […]
Preliminary Data: Schizophrenia and Brain-related Genes May Have Higher Mobile Element Content Similar to that Seen in Autism
We recently wrote and submitted a Letter to the Editor of Neuron in response to the recent article by Bundo et al. (2014) reporting increased LINE1 retrotransposition in schizophrenia genomes. […]
Is the Female Brain More Resilient against Harmful Mutations?
It has long been a topic of debate and discussion whether the lop-sided rates of autism diagnosis (males > females) reflects real gender variations in phenotype or simply diagnostic bias. […]
A Mutation that Lowers Risk for Schizophrenia?
Last month, Rees et al. (2014) reported that, in contrast to copy number variant (CNV) deletions at the genetic locus, 22q11, which increase schizophrenia risk, duplications in that same region […]
The Evolution of Genetic Evolvability
“The hypothesis that evolvability – the capacity to evolve by natural selection – is itself the object of natural selection is highly intriguing but remains controversial due in large part […]
An Update on My Current Work: Bald Mice & Autism Genomics
I gotta be honest: my brain is pretty fried this weekend. After each sentence I type here I find myself staring off into space snatching some microsleep. Ya ever feel […]
Are Changes in the Epigenome Actually due to the Dynamic Nature of DNA?
I could be totally wrong on this one, which is cool. Happens often enough. And I won’t profess to be an expert in epigenetics, though I’m not completely ignorant of […]
Science Over a Cuppa 
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